Multifunctional Dual Cross-Linked Bioadhesive Patch with Low Immunogenic Response and Wet Tissues Adhesion

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Polymer Chemistry

Background:

• Developing effective bioadhesives requires balancing strong adhesion, water resistance, and biocompatibility.
• Existing bioadhesives often struggle to meet all these critical performance criteria simultaneously.

Purpose of the Study:

• To develop a biocompatible and biodegradable protein-based bioadhesive patch (PBP) with enhanced adhesion properties.
• To evaluate the PBP's performance as a biomedical glue for various clinical applications.

Main Methods:

• Fabrication of a protein-based bioadhesive patch (PBP) utilizing metal ion-induced supramolecular interactions.
• Assessment of adhesion strength compared to conventional bioadhesives like polyethylene glycol and fibrin.
• In vitro and in vivo evaluation of biocompatibility and immunogenic response.

Main Results:

• The PBP demonstrated superior adhesion strength on biological surfaces compared to conventional bioadhesives.
• Achieved robust adhesion through interfacial water removal and rapid supramolecular interactions.
• Exhibited negligible immunogenic response, confirming high biocompatibility in vitro and in vivo.

Conclusions:

• The developed PBP offers a promising solution for a biomedical glue, overcoming limitations of current materials.
• Its strong adhesion and biocompatibility support applications in hemostasis, wound healing, and organ sealing.
• The PBP is anticipated to be a valuable tissue adhesive and sealant.