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Updated: Aug 22, 2025
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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
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Deceased donors with multidrug-resistant organisms: implications and future directions
Stephanie M Pouch1, Michael G Ison2
1Emory University School of Medicine, Atlanta, Georgia.
Current Opinion in Organ Transplantation
|November 10, 2022
Summary
Organ donation from donors with multidrug-resistant organisms (MDROs) is inconsistent. Understanding donor MDRO risks and recipient outcomes is crucial for safe organ utilization and minimizing discard.
Area of Science:
- Infectious Diseases
- Transplantation Medicine
- Microbiology
Background:
- Organ utilization from donors colonized with multidrug-resistant organisms (MDROs) is inconsistent.
- Hesitancy stems from potential poor outcomes in solid organ transplant recipients with MDRO donor-derived infections (DDIs).
Approach:
- This review summarizes recent data on MDRO colonization and infection in deceased donors.
- It examines the epidemiology of MDRO DDIs and current management strategies.
- A framework for future research and collaboration is provided.
Key Points:
- Risk factors for donor MDRO acquisition require further delineation.
- Epidemiology of MDRO DDIs needs continued study.
- Optimal donor evaluation, risk stratification, and recipient management approaches are essential.
Conclusions:
- Improved understanding of donor MDROs can safely expand the donor pool.
- Minimizing unnecessary organ discard is a key objective.
- Collaboration is vital for advancing best practices in organ transplantation.
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