Angiotensin-Converting Enzyme 2-Based Biosensing Modalities and Devices for Coronavirus Detection

Area of Science:

• Biomedical Engineering
• Infectious Disease Diagnostics
• Biosensor Technology

Background:

• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, necessitating rapid diagnostic tools.
• Human angiotensin-converting enzyme 2 (hACE2) is the primary receptor for SARS-CoV-2 entry into host cells.
• The host-virus interaction presents an opportunity for novel diagnostic strategies.

Purpose of the Study:

• To review the current status of ACE2-based biosensors for SARS-CoV-2 detection.
• To discuss the principles of signal transduction in these biosensors.
• To explore future development trends, challenges, and prospects for ACE2-based diagnostics.

Main Methods:

• Literature review of recent advancements in ACE2-based SARS-CoV-2 detection modalities.
• Analysis of biosensing devices and their signal transduction mechanisms.
• Discussion of commercial viability and potential applications.

Main Results:

• Several ACE2-based biosensing devices have been developed, demonstrating potential for SARS-CoV-2 detection.
• These biosensors offer rapid and potentially cost-effective solutions for point-of-care diagnostics.
• The technology shows commercial viability and applicability in various settings.

Conclusions:

• ACE2-based biosensing is an emerging approach for COVID-19 diagnostics with significant potential.
• Further research and development are needed to overcome challenges and optimize these tools.
• These biosensors could enhance pandemic control by enabling rapid detection at points of entry and in congregate settings.