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Updated: Aug 22, 2025

Isolation of Chondrocytes and Chondroprogenitors Using Fibronectin Adhesion and Migratory Assay
Published on: October 4, 2024
Articular Cartilage Chondroprogenitors: Isolation and Directed Differentiation
Ilyas M Khan1, Joshua McKenna2, Yadan Zhang2
1Faculty of Medicine, Health & Life Science, Swansea University, Swansea, UK. i.m.khan@swansea.ac.uk.
Abstract:
Experimental data suggests that tissue-specific progenitors are present within hyaline articular cartilage with the potential to contribute to growth, maintenance, and repair. In this chapter, we show how colony-forming progenitor-like cells can be isolated from bovine articular cartilage using differential adhesion to fibronectin. Furthermore, we describe the optimal conditions and factors required to differentiate these progenitor cells to produce hyaline articular cartilage.

