Two new dihydro-β-agarofuran sesquiterpenes from the roots of Celastrus angulatus

Two new dihydro-β-agarofuran sesquiterpenes chiapen T (1) and chiapen U (2), along with chiapen A (3), 1β-hydroxy-2β,6α,12-triacetoxy-8β-(β-nicotinoyloxy)-9β-(benzoyloxy)-β-dihydroagarofuran (4), wilforlide B (5), 3-hydroxy-2-oxo-3-friedelen-29-oic acid (6), epikatonic acid (7), 22-epi-maytenfolic acid (8), maytenoic acid (9), wilforic acid F (10), wilforic acid B (11), were reported for the first time from the Celastrus angulatus. The structures of all the compounds were elucidated by HR-ESI-MS, 1 D and 2 D NMR spectra, as well as single-crystal X-ray diffraction analyses. Compounds 1 and 2 were examined for anti-inflammatory activity, respectively. None of them showed potent activity.