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Histological and Biochemical Analysis after Posterior Mandibular Displacement in Rats.

Ioannis Lyros¹, Despoina Perrea², Konstantinos Tosios³

¹Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Veterinary Sciences

|November 10, 2022

Summary

Mandibular growth restriction in rats caused significant histological changes in condylar cartilage and bone microarchitecture, but did not alter key blood protein levels like OPG, RANKL, and MCSF.

Keywords:

MCSF RANKL class III malocclusion condylar cartilage thickness condylar growth mandibular posterior displacement orthodontic treatment osteoprotegerin rat

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Area of Science:

Biochemistry
Histology
Orthodontics

Background:

Mandibular growth restriction can impact craniofacial development.
Understanding the biochemical and histological consequences is crucial for effective treatment.

Purpose of the Study:

To investigate biochemical and histological changes in rat condyles and mandibles following growth restriction.
To assess the impact of orthodontic/orthopedic interventions on these changes.

Main Methods:

Seventy-two Wistar rats were divided into experimental and control groups.
Blood samples were analyzed for OPG, RANKL, and MCSF concentrations using ELISA.
Histological and histomorphometric analyses were performed on mandibular condyles.

Main Results:

No significant differences in OPG, RANKL, or MCSF serum levels were observed between groups.
Significant histological alterations included reduced Bone Surface/Total Surface ratio.
Posterior condylar cartilage thickness was significantly diminished.

Conclusions:

The applied orthodontic/orthopedic intervention did not significantly affect circulating OPG, RANKL, or MCSF.
Mandibular displacement primarily results in local histological alterations in condylar cartilage and bone microarchitecture.