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Dual trigger vs. Conventional trigger outcomes in In Vitro Fertilization. Systematic review and meta-analysis
Virginia González González1, Alejandra Mayoral Triana1, Irene Serrano García1
1Instituto de Salud de la Mujer. Hospital Clinico San Carlos, Madrid, Spain.
Dual trigger protocols, using human chorionic gonadotropin (hCG) plus GnRH agonists, show improved oocyte retrieval and live birth rates compared to conventional hCG triggers. This suggests dual triggering may enhance fertility outcomes in controlled ovarian stimulation.
Area of Science:
- Reproductive Endocrinology
- Infertility Treatments
- Assisted Reproductive Technologies
Background:
- Controlled ovarian stimulation is a key component of assisted reproductive technologies.
- Ovarian stimulation protocols aim to optimize oocyte yield and quality.
- Triggering final oocyte maturation is a critical step influencing treatment success.
Conclusions:
- Dual trigger appears more effective than conventional hCG trigger for embryo and pregnancy outcomes.
- The benefits of dual trigger are particularly noted in GnRH antagonist cycles.
- Further research may elucidate the full potential of dual trigger protocols.
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