Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

207
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
207
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

157
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
157
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

622
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
622
Drug Dependence01:17

Drug Dependence

1.1K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.1K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

189
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
189
High-Level and Low-Level Awareness01:19

High-Level and Low-Level Awareness

354
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
354

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Capturing lived experience of recovery-oriented mental health care: Psychometric validation of the French Recovery Self-Assessment Scale (RSAR-Fr).

Psychiatric rehabilitation journal·2026
Same author

Memory Performance in Adolescents Living With Obesity: Brain Activation During Encoding and Retrieval in a Case-Control Study.

Obesity science & practice·2026
Same author

Perfectionism in Overweight and Obesity: A Scoping Review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same author

Efficacy and safety of transcranial direct current stimulation in alcohol use disorder: A randomized controlled triple-blind trial.

Addiction (Abingdon, England)·2026
Same author

Depressive symptoms after endovascular thrombectomy are independent of functional outcome.

Journal of neurointerventional surgery·2026
Same author

TrialMatchAI: an end-to-end AI-powered clinical trial recommendation system to streamline patient-to-trial matching.

Nature communications·2026
Same journal

Precision Proteomic Profiling of Systemic Lupus Erythematosus-Correlating Disease Activity and Complement Levels with Clinical Phenotypes.

Biomedicines·2026
Same journal

The Role of Salivary Microbiota in Pancreatic Cancer: From Screening to Tumor Progression and Treatment Response.

Biomedicines·2026
Same journal

Diagnostic Utility of Surface Electromyography for Identifying Muscles Affected by Myofascial Trigger Points: A Scoping Review.

Biomedicines·2026
Same journal

Performance Assessment of a Locally Semi-Automated NGS-Based Workflow for Homologous Recombination Deficiency Testing in High-Grade Serous Ovarian Carcinoma.

Biomedicines·2026
Same journal

Coupling and Uncoupling Pleiotropy Between Hypertension and Type 2 Diabetes Contribute to Exploring Potential Heterogeneity in Cardiovascular Risk in East Asian Population.

Biomedicines·2026
Same journal

Maternal Response to Therapeutic Plasma Exchange in Early Gestation: A Case Series of Thrombotic Microangiopathies and Neurological Disorders.

Biomedicines·2026
See all related articles

Related Experiment Video

Updated: Aug 22, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.9K

The Executive Functioning Paradox in Substance Use Disorders.

Louise Jakubiec1,2,3, Valentine Chirokoff4, Majd Abdallah5

  • 1Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux, UMR 5287, 33000 Bordeaux, France.

Biomedicines
|November 11, 2022
PubMed
Summary
This summary is machine-generated.

Executive functioning, like verbal fluency, influences substance use during craving in individuals with substance use disorders (SUD). Better executive skills may increase relapse risk by heightening craving awareness.

Keywords:
cravingecological momentary assessmentexecutive functionsrelapseresting statersfMRIsubstance use disorders

More Related Videos

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

7.5K
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.6K

Related Experiment Videos

Last Updated: Aug 22, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.9K
A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

7.5K
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.6K

Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Research

Background:

  • Neurocognitive deficits are recognized vulnerabilities in substance use disorders (SUD).
  • The precise role of executive functions in the craving-substance use link and relapse vulnerability requires further elucidation.

Purpose of the Study:

  • To investigate if executive capacities moderate the craving-substance use relationship.
  • To explore the correlation between this influence, brain functional connectivity, and relapse vulnerability.

Main Methods:

  • Combined resting-state functional magnetic resonance imaging (rsfMRI) and ecological momentary assessment (EMA).
  • Neuropsychological testing administered to 86 patients with SUD (alcohol, tobacco, cannabis) and 40 healthy controls.
  • EMA collected real-time craving data; rsfMRI data acquired from 54 patients and 30 controls.

Main Results:

  • In patients with SUD, enhanced verbal fluency and resistance to interference correlated with increased substance use during craving episodes.
  • Preliminary rsfMRI data indicated specific network interactions with executive functions influencing the craving-use association.
  • Better executive functioning may predispose individuals to relapse following craving.

Conclusions:

  • Executive functions, particularly resistance to interference and cognitive flexibility, may increase susceptibility to substance use by modulating attention to craving cues.
  • Findings suggest that individuals with superior executive skills might be paradoxically more vulnerable to relapse after craving episodes.