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Odontogenic Chronic Rhinosinusitis: Structured Histopathology Evidence in Different Patho-Physiological Mechanisms
Giuseppe Brescia1, Lara Alessandrini2, Christian Bacci3
1Otolaryngology Section, Department of Neuroscience DNS, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.
Odontogenic chronic rhinosinusitis (oCRS) shows varied histopathology, with dental implants linked to higher eosinophils and squamous metaplasia. This suggests oCRS is heterogeneous and histopathology aids diagnosis and prognosis.
Area of Science:
- Otorhinolaryngology
- Pathology
- Dental Medicine
Background:
- Increasing rates of odontogenic chronic rhinosinusitis (oCRS) are linked to advances in dental surgery and implantology.
- Understanding the histopathological features of oCRS is crucial for diagnosis and treatment.
Purpose of the Study:
- To characterize the structured histopathology of oCRS surgical specimens.
- To explore associations between histopathological findings and oCRS pathophysiology.
Main Methods:
- Analysis of sinonasal mucosa tissue from 42 oCRS patients.
- Evaluation of histopathological features including eosinophil counts, edema, metaplasia, and fibrosis.
Main Results:
- Significant differences in tissue eosinophil counts, edema, and squamous metaplasia were observed among oCRS subtypes (radicular cysts, dental implants, other dental diseases).
- oCRS associated with dental implants showed higher eosinophil counts.
- Squamous metaplasia was more prevalent in oCRS with radicular cysts compared to dental implants.
Conclusions:
- Structured histopathology is a valuable tool for diagnosing and managing oCRS.
- oCRS is a histopathologically heterogeneous condition.
- oCRS secondary to dental implant issues often presents with a significant eosinophilic component.
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