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Liver Brain Interactions: Focus on FGF21 a Systematic Review.
Eva Prida1, Sara Álvarez-Delgado1, Raquel Pérez-Lois1,2
1Instituto de Investigación Sanitaria de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Travesía da Choupana s/n, 15706 Santiago de Compostela, Spain.
International Journal of Molecular Sciences
|November 11, 2022
Summary
Fibroblast growth factor 21 (FGF21) is a key hormone regulating metabolism and energy balance. This review explores FGF21
Area of Science:
- Metabolic Regulation
- Neuroendocrinology
Background:
- Fibroblast growth factor 21 (FGF21) is a hormone primarily produced by the liver.
- FGF21 plays a crucial role in metabolic adaptation to fasting and nutritional stress.
- It influences energy homeostasis, glucose and lipid metabolism, and insulin sensitivity.
Approach:
- Systematic review of fibroblast growth factor 21's metabolic regulatory functions.
- Analysis of FGF21's interactions with the central nervous system.
- Exploration of therapeutic potential targeting the hepatic-brain axis.
Key Points:
- FGF21 mediates metabolic responses to fasting and starvation.
- FGF21 acts on the central nervous system to regulate energy balance.
- Pharmacological FGF21 therapies show promise for obesity and metabolic disorders.
Conclusions:
- FGF21 is a critical regulator of metabolism via the hepatic-brain axis.
- Understanding FGF21's CNS actions is vital for therapeutic development.
- FGF21 represents a potential therapeutic target for metabolic diseases.
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