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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
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Iron Deficiency in Patients with Advanced Heart Failure
Maria Bakosova1,2, Jan Krejci1,2, Julius Godava1
11st Department of Internal Medicine-Cardioangiology, St. Anne's University Hospital, 60200 Brno, Czech Republic.
Medicina (Kaunas, Lithuania)
|November 11, 2022
Summary
Iron deficiency (ID) is highly prevalent in advanced heart failure patients awaiting transplantation, often without accompanying anemia. This highlights the need for better diagnostic markers in this population.
Area of Science:
- Cardiology
- Hematology
- Nephrology
Background:
- Iron deficiency (ID) is a frequent comorbidity in heart failure patients.
- ID is linked to poorer physical function, increased hospitalizations, and higher mortality.
- Prevalence of ID in advanced heart failure patients awaiting transplantation requires investigation.
Purpose of the Study:
- To determine the prevalence of iron deficiency in patients with advanced heart failure on the heart transplant waiting list.
Main Methods:
- A cohort of 52 heart transplant candidates was studied.
- Iron metabolism parameters were monitored, defining ID by ferritin and transferrin saturation.
- Patients with and without left ventricular assist devices (LVAD) were analyzed.
Main Results:
- Iron deficiency was found in 79% of patients, with only 35% exhibiting anemia.
- ID prevalence was 82% in the non-LVAD group and 57% in the LVAD group.
- ID was associated with chronic renal insufficiency in 40.5% of cases.
Conclusions:
- The majority of advanced heart failure patients have iron deficiency, often without anemia.
- Iron deficiency diagnosis in heart failure requires further research into optimal markers, especially for specific patient subgroups.
- The study underscores the high burden of ID in this critical patient group.
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