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Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals.
Christopher Seifen1, Johannes Pordzik1, Katharina Ludwig1
1Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany.
Medicina (Kaunas, Lithuania)
|November 11, 2022
Summary
Obstructive sleep apnea (OSA) severity in obese individuals correlates with higher HbA1c levels, indicating poorer glycemic control. OSA screening and treatment are crucial for managing diabetes mellitus (DM) risks in obesity.
Area of Science:
- Endocrinology
- Sleep Medicine
- Cardiology
Background:
- Obesity and obstructive sleep apnea (OSA) share common comorbidities like diabetes mellitus (DM) and cardiovascular diseases.
- The intricate relationship between OSA severity, obesity, and these comorbidities requires further elucidation.
Purpose of the Study:
- To investigate the association between OSA severity in obese individuals and polysomnography (PSG)-based sleep parameters.
- To examine the correlation of OSA severity with C-reactive protein (CRP) and glycated hemoglobin (HbA1c) serum levels in obese adults.
Main Methods:
- Retrospective comparison of PSG recordings and blood samples from obese individuals with mild OSA versus moderate/severe OSA.
- Groups were matched for age, sex, and body mass index (BMI).
Main Results:
- Respiratory sleep parameters were significantly higher in the moderate/severe OSA group.
- No significant difference in CRP levels was observed between OSA severity groups.
- HbA1c serum levels were significantly elevated in individuals with moderate/severe OSA.
Conclusions:
- OSA severity significantly impacts glycemic control in obese individuals, suggesting a link to diabetes mellitus development.
- OSA severity does not appear to be associated with systemic inflammation (CRP) in obese individuals.
- Obese individuals may benefit from OSA screening and treatment to mitigate DM-associated risks.
Keywords:
CRPHbA1capnea–hypopnea indexbody mass indexobesity and obstructive sleep apneaobstructive sleep apneaMore Related Videos
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