Comprehensive Phenotyping in Inflammatory Bowel Disease: Search for Biomarker Algorithms in the Transkingdom...

Area of Science:

• Gastroenterology
• Microbiome Research
• Epigenetics

Background:

• Inflammatory Bowel Disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), presents diagnostic challenges due to its heterogeneity.
• IBD involves immune dysregulation against gut microbiota in genetically susceptible individuals.
• Rising IBD incidence in developing regions highlights the need for accessible diagnostic methods.

Purpose of the Study:

• To characterize epigenetic biomarkers and gut microbial profiles in UC and CD patients in the Buenos Aires Metropolitan area.
• To identify differences between IBD patients and non-IBD controls.
• To develop enhanced diagnostic tools by integrating multi-omic data.

Main Methods:

• Analysis of epigenetic biomarkers and gut microbial composition in IBD patients and controls.
• Characterization of microbial metabolic functions and core microorganisms.
• Integration of multi-omic data (clinical, biochemical, epigenetic, microbial) for phenotype discrimination.

Main Results:

• Distinct epigenetic and gut microbial profiles were identified in IBD patients compared to controls.
• Differences in general metabolic functions and core microorganisms were observed.
• The study revealed significant variations between non-IBD controls and IBD patients.

Conclusions:

• This research provides novel insights into the gut microbiome and epigenetics of IBD in the Buenos Aires region.
• The findings support the development of advanced diagnostic tools for IBD phenotyping.
• Integration of trans-kingdom data offers a powerful approach for comprehensive patient stratification.