Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Smartphone-Assisted Approach to Formaldehyde Detection Using Diethanolamine-Grafted Carbon Nanoparticles.

ACS omega·2026
Same author

Synthetic fluorescent receptor arrays for sensing in complex matrices: from robust chemistry to data-driven readouts.

Chemical communications (Cambridge, England)·2026
Same author

Surface plasmon resonance as a breakthrough tool for characterizing the size and shape of graphene quantum dots.

Nanoscale·2026
Same author

Calix[5]arene Functionalized Gold Nanoparticles for the Selective Detection of Polyammonium Species in Water.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Correction of Background in Fluorescence Correlation Spectroscopy for Accurate Determination of Particle Number.

Biomolecules·2026
Same author

Functionalized carbon nanoparticles for smartphone-based sensing of formaldehyde.

Nanoscale advances·2025
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
Same journal

Comparative Phytochemical Studies on the Aerial Parts of <i>Teucrium davaeanum</i> Coss. and <i>Teucrium zanonii</i> Pamp.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Aug 22, 2025

Fluorescent Paper Strips for the Detection of Diesel Adulteration with Smartphone Read-out
07:10

Fluorescent Paper Strips for the Detection of Diesel Adulteration with Smartphone Read-out

Published on: November 9, 2018

9.5K

Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor.

Rossella Santonocito1, Nunzio Tuccitto1,2, Andrea Pappalardo1,3

  • 1Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95100 Catania, Italy.

Molecules (Basel, Switzerland)
|November 11, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel sensor for detecting dopamine, a neurotransmitter, in human fluids. This highly sensitive and reusable sensor utilizes a smartphone for detection, enabling practical applications in health monitoring.

Keywords:
cavitanddopaminesalivasmartphonesupramolecular

More Related Videos

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

1.5K
Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

8.2K

Related Experiment Videos

Last Updated: Aug 22, 2025

Fluorescent Paper Strips for the Detection of Diesel Adulteration with Smartphone Read-out
07:10

Fluorescent Paper Strips for the Detection of Diesel Adulteration with Smartphone Read-out

Published on: November 9, 2018

9.5K
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

1.5K
Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

8.2K

Area of Science:

  • Supramolecular Chemistry
  • Chemical Sensing
  • Materials Science

Background:

  • Dopamine is a crucial neurotransmitter involved in various physiological processes.
  • Accurate and sensitive detection of dopamine is essential for diagnosing and monitoring neurological and physiological conditions.
  • Existing dopamine detection methods often require complex instrumentation or are not suitable for point-of-care applications.

Purpose of the Study:

  • To investigate the supramolecular recognition of dopamine using quinoxaline cavitands.
  • To develop a practical and highly sensitive sensor for dopamine detection in biological fluids.
  • To explore the potential of smartphone-based detection for real-world applications.

Main Methods:

  • Supramolecular recognition studies in solution using fluorescence titrations, ESI-MS, and ROESY measurements.
  • Immobilization of a tetraquinoxaline cavitand onto a siloxane-based polymeric solid support to create a sensor.
  • Detection of dopamine using the developed sensor coupled with a smartphone.
  • Evaluation of sensor selectivity and reusability through acid-base cycling.

Main Results:

  • The study demonstrated effective supramolecular recognition of dopamine by quinoxaline cavitands in solution.
  • A novel sensor was successfully developed by immobilizing a tetraquinoxaline cavitand on a polymer support.
  • The sensor exhibited a linear detection range for dopamine from 10 µM down to 100 pM, with an exceptionally low detection limit of 1 pM.
  • The sensor showed high selectivity for dopamine over other common analytes found in saliva.
  • The developed sensor demonstrated reusability after acid-base treatment cycles.

Conclusions:

  • Quinoxaline cavitands are effective hosts for supramolecular recognition of dopamine.
  • The developed polymer-supported sensor offers highly sensitive and selective dopamine detection.
  • Smartphone integration enables a practical, low-cost, and portable platform for dopamine monitoring.
  • This technology holds significant promise for the development of real-world diagnostic tools for human dopamine detection.