Oats Lower Age-Related Systemic Chronic Inflammation (iAge) in Adults at Risk for Cardiovascular Disease
El Hadji M Dioum1, Kevin L Schneider2, David J Vigerust2
1Quaker Oats Center of Excellence, PepsiCo Health and Nutrition Sciences, Chicago, IL 60607, USA.
Insights
Oat products containing beta-glucan may reduce systemic chronic inflammation (SCI) and improve Inflammatory Age® (iAge®), a marker for healthy aging. This suggests oats have a novel anti-inflammatory role for preventative medicine.
Area of Science:
- Immunology
- Nutritional Science
- Gerontology
Background:
- Cardiovascular disease (CVD) remains a leading global cause of death, often linked to systemic chronic inflammation (SCI).
- Targeting SCI presents a potential strategy for CVD prevention and promoting healthy aging.
- Previous research indicated oat beta-glucan improves cholesterol and cardiovascular risk in adults with borderline high cholesterol.
Purpose of the Study:
- To investigate the effect of an oat product on SCI and clinical outcomes related to healthy aging.
- To assess the impact of the oat product on Inflammatory Age® (iAge®), a novel metric for SCI.
- To explore the potential of oats in functional, preventative, and personalized medicine.
Main Methods:
- A secondary analysis of serum samples from a placebo-controlled randomized clinical trial was conducted.
- The study measured the effects of an oat product (3g beta-glucan) on iAge®, a metric predicting multimorbidity, frailty, and mortality.
- Serum samples were analyzed to identify changes in aging-related proteins, such as Eotaxin-1.
Main Results:
- The oat product significantly improved iAge® in subjects with elevated baseline iAge® (>49.6 years) within two weeks.
- A control group receiving rice showed no significant changes in iAge®.
- The beneficial effect of oats on iAge® was primarily attributed to a reduction in the Eotaxin-1 protein, independent of demographic factors.
Conclusions:
- Oat products demonstrate a novel anti-SCI role, potentially impacting healthy aging.
- The findings suggest oats can reduce Inflammatory Age® by targeting specific aging-related chemokines like Eotaxin-1.
- This research supports the use of oats in functional and personalized medicine for cardiovascular health and longevity.
Abstract:
Despite being largely preventable, cardiovascular disease (CVD) is still the leading cause of death globally. Recent studies suggest that the immune system, particularly a form of systemic chronic inflammation (SCI), is involved in the mechanisms leading to CVD; thus, targeting SCI may help prevent or delay the onset of CVD. In a recent placebo-controlled randomized clinical trial, an oat product providing 3 g of β-Glucan improved cholesterol low-density lipoprotein (LDL) levels and lowered cardiovascular risk in adults with borderline high cholesterol. Here, we conducted a secondary measurement of the serum samples to test whether the oat product has the potential to reduce SCI and improve other clinical outcomes related to healthy aging. We investigated the effects of the oat product on a novel metric for SCI called Inflammatory Age® (iAge®), derived from the Stanford 1000 Immunomes Project. The iAge® predicts multimorbidity, frailty, immune decline, premature cardiovascular aging, and all-cause mortality on a personalized level. A beneficial effect of the oat product was observed in subjects with elevated levels of iAge® at baseline (>49.6 iAge® years) as early as two weeks post-treatment. The rice control group did not show any significant change in iAge®. Interestingly, the effects of the oat product on iAge® were largely driven by a decrease in the Eotaxin-1 protein, an aging-related chemokine, independent of a person’s gender, body mass index, or chronological age. Thus, we describe a novel anti-SCI role for oats that could have a major impact on functional, preventative, and personalized medicine.
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