Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for Formulation of...

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems
• Nanotechnology

Background:

• Lipophilic drugs often exhibit poor oral bioavailability.
• Self-nanoemulsifying drug delivery systems (SNEDDSs) improve drug solubility and absorption.
• Solidification of SNEDDSs offers advantages in handling and stability.

Purpose of the Study:

• To investigate isomalt (GIQ9) as a novel carrier for solid SNEDDSs (S-SNEDDSs).
• To enhance the oral bioavailability of lipophilic curcumin (CUN) using S-SNEDDSs.
• To evaluate the suitability of GIQ9 for encapsulating liquid SNEDDS formulations.

Main Methods:

• S-SNEDDSs were prepared using a surface adsorption technique.
• Formulation variables were optimized using a central composite design (CCD).
• Characterization included DSC, FTIR, XRD, microscopy, dissolution, and pharmacokinetic studies.

Main Results:

• Optimized S-SNEDDSs exhibited a particle size of 97 nm, zeta potential of -26.8 mV, and PDI of 0.354.
• Solidification onto isomalt did not alter drug release compared to liquid SNEDDSs.
• S-SNEDDSs demonstrated a 5.1-fold increase in dissolution rate and a 61.7-fold enhancement in oral bioavailability of curcumin.

Conclusions:

• Isomalt (GIQ9) is a suitable solid carrier for developing S-SNEDDSs.
• This approach significantly improves the oral bioavailability of lipophilic drugs like curcumin.
• Solidification of SNEDDSs using isomalt offers a promising strategy for oral drug delivery.