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Related Experiment Video

Updated: Aug 22, 2025

Real-time Digital Imaging of Leukocyte-endothelial Interaction in Ischemia-reperfusion Injury IRI of the Rat Cremaster Muscle
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Acquisition and Analysis of Microcirculation Image in Septic Model Rats.

Chen Ye1, Mami Kawasaki2, Kazuya Nakano3

  • 1Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan.

Sensors (Basel, Switzerland)
|November 11, 2022
PubMed
Summary

Sepsis impairs microcirculation, affecting blood flow and vessel diameter. This study quantifies these changes using non-contact imaging and shows that thrombomodulin therapy can help restore microcirculation in sepsis models.

Keywords:
blood velocitymicrocirculationrobust principal component analysis (RPCA)sepsisthrombomodulin (TM) alfavessel diameter

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Area of Science:

  • Physiology
  • Medical Imaging
  • Sepsis Research

Background:

  • Microcirculation is crucial for oxygen and nutrient delivery, essential for life.
  • Sepsis significantly disrupts microcirculatory function.
  • Current treatments for sepsis-induced microcirculatory dysfunction exist but require quantitative assessment.

Purpose of the Study:

  • To quantitatively detect sepsis-induced variations and recovery in microcirculation.
  • To assess the potential of non-contact imaging for clinical diagnosis and therapy guidance in sepsis.
  • To evaluate the efficacy of thrombomodulin (TM) therapy in restoring sepsis-affected microcirculation.

Main Methods:

  • A non-contact imaging setup was employed to capture microcirculation images in rat models.
  • Rats were divided into sham (control), sepsis (cecum ligation and puncture - CLP), and sepsis with TM therapy groups.
  • Blood velocity was estimated using robust principal component analysis (RPCA) and U-net, while blood vessel diameter was determined by contrast differences.

Main Results:

  • A continuous degradation of blood velocity and blood vessel diameter was observed in the CLP group.
  • The CLP+TM group showed recovery of blood velocity and blood vessel diameter after initial degradation.
  • Quantitative observations demonstrated the impact of sepsis and TM therapy on microcirculatory parameters.

Conclusions:

  • Non-contact imaging provides a quantitative method to assess microcirculation changes in sepsis.
  • Sepsis significantly alters blood velocity and vessel diameter.
  • Thrombomodulin (TM) therapy shows potential in recovering sepsis-induced microcirculatory dysfunction.