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Bionic Engineered Protein Coating Boosting Anti-Biofouling in Complex Biological Fluids
Ziqian Zhao1, Mingfei Pan1, Chenyu Qiao1
1Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, T6G 1H9, Canada.
Advanced Materials (Deerfield Beach, Fla.)
|November 11, 2022
Summary
Engineered proteins with a bionic structure resist biofouling on medical devices. This novel approach uses grafted sulfobetaine methacrylate (SBMA) segments on bovine serum albumin (BSA) for superior antifouling coatings in biological fluids.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Biomedical Engineering
Background:
- Implantable medical devices face dysfunction and infection from biofouling.
- Existing antifouling coatings often require complex surface preparation.
Purpose of the Study:
- To engineer a protein-based antifouling surface coating inspired by natural structures.
- To develop a facile and surface-independent coating method for medical applications.
Main Methods:
- Grafting sulfobetaine methacrylate (SBMA) segments onto bovine serum albumin (BSA) to create BSA@PSBMA.
- Utilizing a simple dipping/spraying method for surface coating.
- Conducting interfacial molecular force measurements and adsorption tests.
Main Results:
- BSA@PSBMA coatings demonstrated facile and surface-independent application.
- Strong interfacial hydration and steric repulsion significantly suppressed substrate-foulant attraction.
- Surfaces exhibited superior resistance to fouling by proteins, metabolites, cells, and biofluids.
Conclusions:
- Engineered proteins offer an innovative solution for antifouling applications in complex biological environments.
- The bionic structure of BSA@PSBMA provides extraordinary antifouling capabilities.
- This approach presents a new paradigm for creating advanced biomaterials for bioengineering.
