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Predicting neonatal mortality with a disseminated intravascular coagulation scoring system
Hayato Go1, Kei Ogasawara2, Hajime Maeda2
1Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan. gohayato2525@gmail.com.
International Journal of Hematology
|November 11, 2022
Summary
Neonatal disseminated intravascular coagulation (DIC) mortality is difficult to predict. A scoring system using Japan Society of Obstetrical, Gynecological & Neonatal Hematology (JSOGNH) 2016 criteria effectively predicts mortality in infants with DIC.
Area of Science:
- Neonatal Hematology
- Critical Care Medicine
- Pediatric Coagulopathy
Background:
- Disseminated intravascular coagulation (DIC) poses a significant mortality risk in neonates.
- Predicting mortality in neonatal DIC remains a clinical challenge.
Purpose of the Study:
- To investigate underlying conditions associated with neonatal DIC.
- To evaluate a scoring system for predicting mortality in neonatal DIC.
Main Methods:
- Retrospective evaluation of DIC scores in neonates diagnosed on or after day 2 of life.
- Diagnosis of DIC based on Japan Society of Obstetrical, Gynecological & Neonatal Hematology (JSOGNH) 2016 criteria.
- Analysis of underlying conditions and their association with DIC and mortality.
Main Results:
- Gastrointestinal perforation/necrotizing enterocolitis and congenital heart disease were common in neonates with DIC.
- Birth weight, gestational age, D-dimer, and fibrinogen levels did not predict mortality.
- Median PT-INR and DIC scores were significantly higher in non-survivors.
- DIC scores showed significant differences based on survival outcome (P=0.013).
Conclusions:
- DIC scores derived from JSOGNH 2016 neonatal criteria can predict mortality.
- The scoring system is valuable for infants diagnosed with DIC on or after the second day of life.
