Related Experiment Video
Updated: Aug 22, 2025
11:31
Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
Published on: July 4, 2018
12.4K
CD147 and MMPs as key factors in physiological and pathological processes
Rezvan Asgari1, Asad Vaisi-Raygani2, Mohammad Sajad Emami Aleagha3
1Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 12, 2022
Summary
Cluster of differentiation 147 (CD147), also known as extracellular matrix metalloproteinase inducer (EMMPRIN), regulates matrix metalloproteinases (MMPs). This review explores their roles in physiological and pathological processes, highlighting disease associations.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Cluster of differentiation 147 (CD147), or extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein.
- CD147 induces the synthesis of matrix metalloproteinases (MMPs), which are crucial for extracellular matrix (ECM) degradation.
- Dysregulation of CD147 and MMPs is linked to various diseases.
Purpose of the Study:
- To review the critical roles of CD147 and MMPs in major physiological processes.
- To examine the involvement of CD147 and MMPs in pathological conditions.
- To highlight the significance of CD147 and MMPs in disease pathogenesis.
Main Methods:
- Literature review of scientific articles focusing on CD147 and MMPs.
- Analysis of the molecular mechanisms underlying CD147-MMP interactions.
- Synthesis of information on the physiological and pathological functions of CD147 and MMPs.
Main Results:
- CD147's role as an inducer of MMP synthesis is confirmed.
- MMPs are identified as key enzymes in ECM remodeling, cellular signaling, and protein processing.
- Disordered expression or function of CD147 and MMPs are associated with diverse pathologies.
Conclusions:
- CD147 and MMPs are integral to numerous physiological functions.
- Aberrant CD147 and MMP activity contributes significantly to disease development.
- Further research into CD147 and MMPs may reveal therapeutic targets for various diseases.
More Related Videos
Related Concept Videos
01:23Role of Matrix Metalloproteases in Degradation of ECM
2.5K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.5K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
01:24Regulation of Angiogenesis and Blood Supply
2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
01:42Microtubule Associated Proteins (MAPs)
4.5K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
4.5K
01:19Interactions Between Signaling Pathways
6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K