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Updated: Aug 22, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

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Targeting CSC-related transcription factors by E3 ubiquitin ligases for cancer therapy

Weijia Wang1, Wenjun Liu2, Qiuli Chen3

  • 1Clinical Laboratory Center of Medicine, Zhongshan People's Hospital, Zhongshan, 528403 Guangdong, China.

Seminars in Cancer Biology
|November 12, 2022
PubMed

Insights

Transcription factors regulate cell processes like cancer stem cell formation and metastasis. Targeting E3 ubiquitin ligases offers therapeutic potential for modulating these factors in cancer.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • Transcription factors are crucial regulators of cellular processes, including cancer stem cell (CSC) formation, metastasis, and chemoresistance.
  • Dysregulated transcription factor expression drives tumorigenesis and cancer progression.
  • Signaling pathways, noncoding RNAs, and E3 ubiquitin ligases tightly control transcription factor expression.

Purpose of the Study:

  • To review the critical roles of CSC-related transcription factors.
  • To discuss E3 ligases that regulate the degradation of CSC-related transcription factors and their mechanisms.
  • To examine EMT-associated transcription factors and highlight therapeutic strategies targeting E3 ligases.

Main Methods:

  • Literature review of scientific articles on transcription factors, cancer stem cells, EMT, and E3 ubiquitin ligases.
  • Analysis of regulatory mechanisms involving E3 ligases in transcription factor degradation.
  • Synthesis of information on therapeutic targeting of E3 ligases for cancer treatment.

Main Results:

  • Identified key transcription factors involved in CSC formation (e.g., Oct4, SOX2, Nanog).
  • Detailed mechanisms by which E3 ligases control the stability of these CSC-related transcription factors.
  • Summarized functions of EMT-associated transcription factors (e.g., ZEB1, Snail) and their regulatory networks.

Conclusions:

  • Transcription factors are pivotal in cancer development and progression, particularly through CSCs and EMT.
  • E3 ubiquitin ligases represent promising therapeutic targets for modulating CSC and EMT transcription factors.
  • Targeting E3 ligases offers a potential strategy to control cancer metastasis, recurrence, and chemoresistance.
Keywords:
CSCE3 ligasesEMTOncogeneTranscription factor

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