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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Related Experiment Video

Updated: Aug 22, 2025

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Immuno(T)herapy for age-related diseases.

Enrique Gabandé-Rodríguez1,2, Matilda Pfeiffer1, María Mittelbrunn2,3

  • 1Departamento de Biología Molecular, Facultad de Ciencias (UAM), Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain.

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T-cell-based immunotherapies, including checkpoint inhibitors and chimeric antigen receptor T-cells, are revolutionizing cancer treatment. These approaches show promise for treating age-associated diseases in GeroScience, expanding immunotherapy

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Area of Science:

  • Immunology
  • Oncology
  • GeroScience

Background:

  • Immunosuppressive checkpoint blockade has significantly advanced cancer therapy.
  • Chimeric antigen receptor (CAR) T-cell technology offers a potent treatment for hematological neoplasms.
  • Emerging evidence suggests immunotherapy's applicability beyond oncology.

Purpose of the Study:

  • To discuss the emergence of T-cell-based immunotherapies.
  • To highlight their potential in treating non-oncological, age-associated diseases.
  • To explore their future impact on GeroScience.

Main Methods:

  • Review of recent evidence on T-cell-based immunotherapies.
  • Commentary on the expansion of immunotherapy to non-oncological applications.
  • Discussion of therapeutic potential in age-associated disorders.

Main Results:

  • T-cell-based immunotherapies have shown remarkable success in cancer treatment.
  • These therapies are being explored for non-oncological conditions, particularly age-related diseases.
  • Significant therapeutic potential exists for the elderly population.

Conclusions:

  • T-cell-based immunotherapies represent a paradigm shift in medicine.
  • Their application in GeroScience could offer novel treatment strategies for age-associated disorders.
  • These approaches are poised to revolutionize the future of GeroScience.