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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Comorbidities among Egyptian systemic lupus erythematosus: The COMOSLE-EGYPT study
Sherif M Gamal1, Abir Mokbel1,2, Marwa H Niazy1
1Rheumatology Department, Cairo University, Cairo, Egypt.
Chronic Illness
|November 14, 2022
Summary
Systemic lupus erythematosus (SLE) patients frequently experience comorbidities like hypertension and dyslipidemia. Multiple comorbidities significantly increase mortality risk in SLE patients, highlighting the need for comprehensive management.
Area of Science:
- Rheumatology
- Internal Medicine
- Epidemiology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with significant morbidity.
- Comorbidities are common in SLE patients and can impact disease outcomes.
Purpose of the Study:
- To investigate the prevalence and impact of comorbidities in a cohort of Egyptian patients with SLE.
- To identify factors associated with the presence of comorbidities and their effect on mortality.
Main Methods:
- Retrospective, multicenter study of 902 Egyptian SLE patients.
- Review of medical records for demographics, clinical data, laboratory findings, and medications.
- Calculation of SLE Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics/American College Rheumatology Damage Index scores.
Main Results:
- Comorbidities were present in 75.5% of patients, with hypertension (43.1%) and dyslipidemia (40.1%) being most common.
- Age, disease duration, SLEDAI at onset, cyclophosphamide use, and methylprednisone treatment were associated with comorbidities.
- Multiple comorbidities increased the odds of mortality by 18.5 times (OR, 95% CI = 18.5 (6.65-51.69)).
Conclusions:
- Comorbidities are highly prevalent in SLE patients and are linked to disease activity and treatment.
- The presence of multiple comorbidities significantly elevates the risk of mortality in SLE.
- Effective management of comorbidities is crucial for improving outcomes in SLE patients.
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