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Related Concept Videos

Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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Nuclear Protein Sorting01:34

Nuclear Protein Sorting

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Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
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Role of Septins01:02

Role of Septins

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Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Related Experiment Video

Updated: Aug 22, 2025

Expression, Purification, and Liposome Binding of Budding Yeast SNX-BAR Heterodimers
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Expression, Purification, and Liposome Binding of Budding Yeast SNX-BAR Heterodimers

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[Sorting Nexin 16:Structure,Function,and Role in Diseases].

Fei-Yan Zeng1, Yue-Fen Lou1

  • 1Department of Pharmacy,Shanghai Fourth People's Hospital Affiliated to Tongji University,Shanghai 200434,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|November 14, 2022
PubMed
Summary
This summary is machine-generated.

Sorting nexin 16 (SNX16) is crucial for cellular processes like endocytosis and protein sorting. Understanding SNX16

Keywords:
biological functiondiseasessorting nexin16structural characteristics

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Area of Science:

  • Molecular Biology
  • Cell Biology

Background:

  • Sorting nexin 16 (SNX16) is a key protein involved in various cellular functions.
  • SNX16 possesses a phox homology domain for binding phosphatidylinositol-3-phosphate and a coiled-coil domain.
  • Dysfunction of SNX16 is linked to the development of several diseases.

Approach:

  • This review synthesizes current knowledge on SNX16 structure and function.
  • It examines the regulatory role of SNX16 in disease pathogenesis.
  • The review explores potential therapeutic applications of SNX16.

Key Points:

  • SNX16's structural domains dictate its cellular roles.
  • SNX16 is integral to endocytosis, protein sorting, and signal transduction pathways.
  • Altered SNX16 activity contributes to disease development.

Conclusions:

  • SNX16 is a multifaceted protein with significant implications in health and disease.
  • Targeting SNX16 may offer novel therapeutic strategies for related disorders.
  • Further research into SNX16 biology can advance disease prevention and treatment.