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Updated: Aug 22, 2025

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
Published on: September 4, 2017
Autonomous digitizer calibration of a Monte Carlo detector model through evolutionary simulation
Matthew Herald1, Andrei Nicuşan2, Tzany Kokalova Wheldon3,4
1School of Chemical Engineering, University of Birmingham, Birmingham, UK. mxh1092@bham.ac.uk.
Abstract:
Simulating the response of a radiation detector is a modelling challenge due to the stochastic nature of radiation, often complex geometries, and multi-stage signal processing. While sophisticated tools for Monte Carlo simulation have been developed for radiation transport, emulating signal processing and data loss must be accomplished using a simplified model of the electronics called the digitizer. Due to a large number of free parameters, calibrating a digitizer quickly becomes an optimisation problem. To address this, we propose a novel technique by which evolutionary algorithms calibrate a digitizer autonomously. We demonstrate this by calibrating six free parameters in a digitizer model for the ADAC Forte. The accuracy of solutions is quantified via a cost function measuring the absolute percent difference between simulated and experimental coincidence count rates across a robust characterisation data set, including three detector configurations and a range of source activities. Ultimately, this calibration produces a count rate response with 5.8% mean difference to the experiment, improving from 18.3% difference when manually calibrated. Using evolutionary algorithms for model calibration is a notable advancement because this method is novel, autonomous, fault-tolerant, and achieved through a direct comparison of simulation to reality. The software used in this work has been made freely available through a GitHub repository.
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