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Updated: Aug 22, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants
Julide Sisman1, Rachel L Leon2, Brooke W Payton2
1Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. julide.sisman@utsouthwestern.edu.
Objective:
Our aim was to examine the frequency and type of placental abnormalities in neonates with LSV.
Study Design:
We prospectively reviewed cranial ultrasounds (cUS) from neonates born at ≤32 weeks of gestation at Parkland Hospital between 2012 and 2014. Our cohort included neonates with LSV and gestational age and sex matched controls with normal cUS. We retrieved placental pathology reports retrospectively and compared placental abnormalities in both groups.
Results:
We reviewed 1351 cUS from a total of 407 neonates. Placental pathology evaluations were complete for 64/65 (98%) neonates with LSV and 68/70 (97%) matched controls. There were no significant differences for any type of placental abnormities between LSV and control groups. However, infants with highest stage LSV were more likely to have large for gestational age (LGA) placentas (p = 0.01).
Conclusion:
The association between LSV and LGA placenta may indicate a shared vascular response to an adverse prenatal environment.
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