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Biomarkers predicting central serous chorioretinopathy episode persistence
Peter Kiraly1,2,3, Jaka Smrekar4, Polona Jaki Mekjavić2,3,5
1574106Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
European Journal of Ophthalmology
|November 15, 2022
Summary
Biomarkers like female sex, older age, wider pigment epithelial detachment (PED), more hyperreflective foci (HF), thinner choroid, and diffuse retinal pigment epithelial (RPE) alterations predict persistent central serous chorioretinopathy (CSC). These findings aid in early intervention for at-risk patients.
Area of Science:
- Ophthalmology and Visual Sciences
- Medical Imaging and Diagnostics
- Retinal Diseases Research
Background:
- Central serous chorioretinopathy (CSC) is a condition affecting vision, characterized by fluid accumulation under the retina.
- Identifying predictors of persistent CSC episodes is crucial for timely and effective treatment strategies.
- Understanding baseline biomarkers can help stratify patients at higher risk of prolonged disease duration.
Purpose of the Study:
- To identify specific biomarkers present at the initial presentation of central serous chorioretinopathy (CSC).
- To determine which clinical and imaging features are associated with a persistent CSC episode.
- To provide insights for early therapeutic interventions in patients likely to experience prolonged CSC.
Main Methods:
- Prospective study involving 35 patients diagnosed with acute CSC.
- Evaluation of potential biomarkers including demographics, clinical history, and optical coherence tomography (OCT) imaging features.
- Biomarkers assessed at baseline and 3 months included central retinal thickness (CRT), macular volume (MV), choroidal thickness (CT), pigment epithelial detachment (PED) dimensions, retinal hyperreflective foci (HF), and retinal pigment epithelial (RPE) alterations.
Main Results:
- At 3 months, 16 out of 35 patients experienced persistent CSC episodes.
- Persistent CSC was significantly associated with female sex (p=0.032), older age (p=0.015), wider PED (p=0.005), and a higher number of HF (p=0.02).
- A thinner choroid and diffuse RPE alterations, when considered together, were also significantly linked to persistent episodes (p=0.008).
Conclusions:
- Older female patients with specific baseline characteristics are more prone to persistent CSC.
- Key indicators for persistence include wider PED, increased HF, thinner choroid, and diffuse RPE alterations.
- These identified biomarkers suggest that earlier treatment may benefit patients with a higher likelihood of persistent CSC episodes.
