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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Delivery systems for fucoxanthin: Research progress, applications and future prospects.

Zimo Zhang1, Zihao Wei1, Changhu Xue1,2

  • 1College of Food Science and Engineering, Ocean University of China, Qingdao, China.

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Fucoxanthin, a beneficial algae-derived compound, faces application challenges due to instability and poor solubility. Delivery systems are crucial for enhancing its stability and bioavailability for improved food and health applications.

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Area of Science:

  • Marine natural products
  • Nutraceuticals and functional foods
  • Biomaterials and drug delivery

Background:

  • Fucoxanthin, a marine keto-carotenoid from algae, offers significant health benefits and food quality improvements.
  • Its application is limited by poor stability, low water solubility, and reduced oral bioavailability due to its unsaturated structure.
  • Despite abundance, challenges hinder widespread use in the food industry.

Purpose of the Study:

  • To review and summarize various delivery systems designed for fucoxanthin.
  • To highlight how these systems enhance fucoxanthin's stability and oral bioavailability.
  • To discuss the impact of delivery systems on intestinal absorption and future application trends.

Main Methods:

  • Literature review focusing on fucoxanthin delivery systems.
  • Analysis of studies on encapsulation, protection, and release mechanisms.
  • Examination of research on intestinal epithelial cell absorption and bioavailability.

Main Results:

  • Delivery systems effectively mitigate fucoxanthin's instability under adverse conditions.
  • Encapsulation significantly improves fucoxanthin's oral bioavailability.
  • Delivery systems influence the absorption of fucoxanthin by intestinal cells.

Conclusions:

  • Well-designed delivery systems are essential for overcoming fucoxanthin's limitations.
  • Further research into novel delivery systems, extraction, and industrial production is recommended.
  • Delivery systems offer a promising avenue for maximizing fucoxanthin's health and food applications.