Related Experiment Video
Updated: Aug 21, 2025

13:21
Determining heat and mechanical pain threshold in inflamed skin of human subjects
Published on: January 14, 2009
20.9K
Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating
Journal of Pain & Palliative Care Pharmacotherapy
|November 15, 2022
Summary
Transdermal fentanyl patches may be less effective for patients experiencing significant sweating due to hot flashes or unknown causes. Monitoring for sweating and adjusting pain management strategies are crucial for effective cancer pain relief.
Area of Science:
- Oncology
- Pain Management
- Pharmacology
Background:
- Cancer patients often require effective pain management, with transdermal fentanyl patches (TDF) being a common option.
- Prostate cancer and thymoma with metastasis are serious conditions requiring robust analgesic strategies.
Observation:
- Excessive sweating, triggered by hot flashes or of unknown origin, interfered with TDF adhesion and efficacy in two cancer patients.
- In one case, TDF adherence issues led to discontinuation, while in another, increased dosage did not improve pain control despite measurable fentanyl blood levels.
Findings:
- Significant sweating can impair the absorption and effectiveness of transdermal fentanyl patches.
- Patient monitoring for sweating is essential when prescribing TDF, as it can impact drug delivery and pain management.
Implications:
- Clinical practice should include vigilant monitoring of sweating in patients using TDF for pain relief.
- Alternative pain management strategies may be necessary for patients experiencing sweating-related issues with TDF.
- Optimizing pain control through medication adjustment can improve the quality of life for cancer patients.
Related Concept Videos
Drug Delivery: Miscellaneous Routes
438
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
438
Decreased Body Temperature
669
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
669
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
360
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
360
Drug Excretion: Miscellaneous Routes
103
Drug excretion involves various organs, including the liver, intestines, skin, and eyes. In the case of drugs or toxins, they can be actively secreted into bile by transporters in the hepatocyte's canalicular membrane. These substances enter the GI tract during digestion and may be reabsorbed into the body from the intestine. This process, known as enterohepatic recycling, can significantly prolong the presence and effects of a substance in the body. To interrupt this cycle, specific...
103
Methods of reducing fever
729
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
729
Non-Oral Extravascular Drug Absorption Routes
264
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
264

