Analysis of the Saliva Proteome Using 2D-DIGE

Saliva is now an established biofluid with a number of important applications in use across research and clinical settings. Saliva contains an assortment of biomolecules, including proteins, metabolites, RNA, DNA, and microorganisms. Numerous biomolecules enter saliva from the blood by passing through the intercellular spaces, reflecting the physiological state of the body. Saliva can be collected directly or using one of the numerous devices/systems that are available, each of which has its own specific applications. The identification and classification of salivary biomolecules, using increasing advanced omics approaches, have contributed to the reality that saliva is a creditable diagnostic fluid for oral and systemic diseases.