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Related Experiment Video

Updated: Aug 21, 2025

Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window

Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window

Published on: November 20, 2012

Decoding vesicle-based precision oncology in gliomas.

Syeda Maheen Batool¹, Tiffaney Hsia¹, Sirena K Khanna¹

¹Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

Neuro-Oncology Advances

|November 16, 2022

Summary

This summary is machine-generated.

Extracellular vesicles (EVs) offer a minimally invasive liquid biopsy for glioma, detecting tumor biomarkers in plasma. This review covers EV isolation and analysis methods for clinical applications.

Keywords:

extracellular vesicles glioma liquid biopsy plasma

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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Area of Science:

Oncology
Biochemistry
Molecular Biology

Background:

Extracellular vesicles (EVs) are crucial in liquid biopsy for glioma, offering diagnostic and prognostic insights.
EV-based liquid biopsy is less invasive and more cost-effective than traditional tissue biopsy.
Tumor-derived EVs carry molecular biomarkers (DNA, RNA, proteins) reflecting glioma dynamics.

Purpose of the Study:

To review current methods for isolating, quantifying, and characterizing plasma EVs in glioma patients.
To discuss the advantages and disadvantages of various EV analysis techniques.
To explore the clinical translational opportunities and challenges of EV-based liquid biopsy for glioma.

Main Methods:

Review of commercial and noncommercial methods for plasma EV isolation and quantification.
Analysis of techniques for biochemical characterization, including whole EV analysis, mutation detection, and genomic/proteomic profiling.

Main Results:

Plasma EVs provide valuable molecular information for glioma diagnosis, prognosis, and treatment monitoring.
Various isolation and analytical methods have distinct advantages and limitations.
Current techniques allow for comprehensive profiling of EV cargo.

Conclusions:

EV-based liquid biopsy holds significant clinical potential for glioma management.
Addressing challenges in standardization and validation is crucial for clinical implementation.
Further research is needed to optimize EV analysis for routine glioma care.