Related Experiment Video

Updated: Aug 21, 2025

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
10:22

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

8.8K

Molecular phylogeny of human adenovirus type 41 lineages

Jasper Götting1, Anne K Cordes1, Lars Steinbrück1

  • 1Institute of Virology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany.

Virus Evolution
|November 16, 2022
PubMed

Insights

Human adenovirus species F type 41 (HAdV-F41) shows significant evolution, particularly in Lineage 3, impacting its tropism and virulence. This study details HAdV-F41

Area of Science:

  • Virology
  • Molecular Biology
  • Genetics

Background:

  • Human adenovirus species F type 41 (HAdV-F41) is a common cause of childhood gastroenteritis.
  • Recent associations with severe pediatric hepatitis have increased interest in HAdV-F41.
  • Limited studies have explored the evolutionary dynamics of HAdV-F41.

Purpose of the Study:

  • To investigate the phylogenetic evolution of HAdV-F41.
  • To analyze genomic variations within HAdV-F41 lineages.
  • To understand potential impacts of evolutionary changes on HAdV-F41 characteristics.

Main Methods:

  • Generation of complete HAdV-F41 genomic sequences from diagnostic specimens (2011-2022).
  • Inclusion of existing HAdV-F41 genomes from GenBank for phylogenetic analysis.
  • Phylogenetic analysis of 65 HAdV-F41 genomes to identify lineages and evolutionary patterns.

Main Results:

  • Phylogenetic analysis revealed three co-circulating HAdV-F41 lineages.
  • Lineage 3, first described in 2009, showed significant evolution, including a deletion in the long fiber gene.
  • A 2022 Lineage 3 isolate exhibited recombinant phylogeny in the short fiber gene, indicating ongoing evolution.

Conclusions:

  • HAdV-F41 has evolved into distinct lineages with significant genetic changes, especially in Lineage 3.
  • Alterations in fiber genes and E3 region of Lineage 3 may influence cellular tropism and virulence.
  • Further research is needed to understand the clinical implications of HAdV-F41 evolution, particularly concerning recent hepatitis cases.

Keywords:
F41adenovirusesevolutionhepatitisphylogenyrecombination

More Related Videos

Engineering and Evolution of Synthetic Adeno-Associated Virus AAV Gene Therapy Vectors via DNA Family Shuffling21:55

Engineering and Evolution of Synthetic Adeno-Associated Virus AAV Gene Therapy Vectors via DNA Family Shuffling

Published on: April 2, 2012

28.6K
Cloning and Large-Scale Production of High-Capacity Adenoviral Vectors Based on the Human Adenovirus Type 513:17

Cloning and Large-Scale Production of High-Capacity Adenoviral Vectors Based on the Human Adenovirus Type 5

Published on: January 28, 2016

14.5K

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.1K
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.7K
Synteny and Evolution02:31

Synteny and Evolution

John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.3K
Phylogeny01:23

Phylogeny

Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
45.3K
Phylogenetic Trees03:21

Phylogenetic Trees

Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
45.9K
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.6K