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Disorders of the Nervous Tissue01:28

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Updated: Aug 21, 2025

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Perspective: COVID-19 and Its Neurologic Sequelae.

Aaron Rothstein1, Christopher Favilla1, Kelly Sloane1

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Summary

The COVID-19 pandemic caused a global health crisis, impacting the nervous system and leading to neurological disability. This review examines current knowledge on these neurological effects and identifies research gaps in treatment and epidemiology.

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Area of Science:

  • Neurology
  • Public Health
  • Infectious Diseases

Background:

  • The COVID-19 pandemic, originating in 2019, rapidly escalated into a global public health emergency.
  • While primarily a respiratory illness, SARS-CoV-2 significantly affects the central and peripheral nervous systems.
  • These neurological impacts contribute to long-term disability in affected individuals.

Purpose of the Study:

  • To consolidate current understanding of the neurological sequelae following COVID-19 infection.
  • To identify critical knowledge gaps concerning the treatment of COVID-19-associated neurological disorders.
  • To highlight unmet needs in the epidemiological study of these neurological complications.

Main Methods:

  • This work is a perspective review, synthesizing existing research and clinical observations.
  • Literature review focusing on neurological manifestations and outcomes of COVID-19.
  • Analysis of current therapeutic strategies and epidemiological data.

Main Results:

  • COVID-19 presents a wide spectrum of neurological complications affecting both central and peripheral nervous systems.
  • Significant gaps exist in understanding the precise mechanisms, long-term prognosis, and effective treatments for these neurological sequelae.
  • Epidemiological data on the prevalence and incidence of neurological conditions post-COVID-19 are incomplete.

Conclusions:

  • Neurological sequelae are a significant and often debilitating consequence of COVID-19.
  • Further research is urgently needed to address the treatment and epidemiological uncertainties surrounding these neurological conditions.
  • A comprehensive approach is required to manage and mitigate the long-term neurological impact of the pandemic.