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Transient Global Amnesia Recurrence: Prevalence and Risk Factor Meta-analysis.
Micaela Anahí Hernández1, Julieta E Arena1, Lucas Alessandro1
1Neurology Department (MAH, JEA, LA, RFA, ILC), Fleni; Department of Movement Disorders (JEA), Fleni; and Department of Cognitive Neurology (RFA, ILC), Neuropsychology and Neuropsychiatry, Fleni, Buenos Aires, Argentina.
Transient global amnesia (TGA) recurrence affects about 1 in 8 patients. Risk factors include migraine, depression, and sexual activity, aiding clinical counseling.
Area of Science:
- Neurology
- Amnestic Disorders
Background:
- Transient global amnesia (TGA) is an acute neurological condition characterized by temporary memory loss.
- While generally benign, TGA recurrence is a significant patient concern due to unclear pathophysiology.
Purpose of the Study:
- To determine the prevalence of TGA recurrence.
- To identify key risk factors associated with TGA relapse for improved patient counseling.
Main Methods:
- Systematic review and meta-analysis of 36 observational studies (1985-2021).
- Included 4,514 TGA cases screened from MEDLINE, Lilacs, and Embase databases.
- Assessed risk factors using random-effect models and odds ratios (OR).
Main Results:
- The overall recurrence rate for TGA was 12.73%.
- Significant risk factors for recurrence included sexual activity (trigger), personal history of migraine, and current depression.
- Migraine history increased risk by 2x; depression by 4x.
Conclusions:
- Approximately 12.73% of TGA patients experience recurrence.
- Migraine, depression, and sexual activity are significant predictors of TGA relapse.
- Identifying these risk factors can enhance clinical guidance for TGA patients.
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