Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoxia01:23

Hypoxia

1.2K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.2K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

316
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
316
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
Physiological Control of Respiration01:23

Physiological Control of Respiration

2.3K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
2.3K
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

1.2K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.2K
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

284
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
284

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pyrazinamide susceptibility testing in <i>Mycobacterium tuberculosis</i>: impact of false-positive BD MGIT 960 results and added value of sequencing for accurate diagnosis in a low-MDR-TB-incidence context.

Frontiers in cellular and infection microbiology·2026
Same author

Sickle cell disease-associated pulmonary hypertension: an integrated framework linking pathologies, mechanisms, and clinical phenotypes.

EBioMedicine·2026
Same author

Strengthening regional surveillance: MenMap Network's year 1 findings on bacterial meningitis in Jordan, Egypt, and Iraq (2023-2024).

IJID regions·2026
Same author

Economic burden of pulmonary arterial hypertension in Switzerland.

PloS one·2026
Same author

Invasive meningococcal disease rebound in older adults post-COVID-19 pandemic: A targeted literature and surveillance review.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

High-flow nasal oxygen for the relief of persistent dyspnea in adult patients with cancer: A systematic review and meta-analysis.

Palliative medicine·2026

Related Experiment Video

Updated: Aug 21, 2025

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

8.9K

[Hypoxemia: from pathophysiology to diagnosis].

Florence Coste1, Argyro Vraka2, Ivan Guerreiro3

  • 1Service de médecine interne, Hôpitaux universitaires de Genève, 1211 Genève 14.

Revue Medicale Suisse
|November 16, 2022
PubMed
Summary
This summary is machine-generated.

Hypoxemia, or low arterial oxygen, can cause tissue hypoxia. This article outlines five causes and a diagnostic strategy for effective hypoxemia management.

More Related Videos

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

2.8K
Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

85.2K

Related Experiment Videos

Last Updated: Aug 21, 2025

A Model to Simulate Clinically Relevant Hypoxia in Humans
09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

8.9K
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

2.8K
Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

85.2K

Area of Science:

  • Respiratory Physiology
  • Clinical Medicine

Context:

  • Hypoxemia is a common clinical issue with serious implications.
  • Prompt diagnosis is crucial for guiding patient management.

Purpose:

  • To review the primary causes of hypoxemia.
  • To outline a systematic diagnostic approach for hypoxemia evaluation.

Summary:

  • Hypoxemia is defined as reduced partial pressure of oxygen in arterial blood.
  • Five key pathophysiological mechanisms underlie hypoxemia: alveolar hypoventilation, V/Q mismatches, diffusion impairment, intrapulmonary shunts, and reduced inspired oxygen.
  • This review synthesizes etiologies based on respiratory pathophysiology.

Impact:

  • Provides a framework for clinicians to diagnose and manage hypoxemia.
  • Aims to improve patient outcomes by facilitating timely and accurate diagnosis.