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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Sugar and spice: Fc glycosylation in antibody-mediated transplant rejection
1Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.
Cell Reports. Medicine
|November 17, 2022
Abstract:
Bharadwaj et al.1 demonstrate that anti-donor HLA antibodies display low levels of Fc fucosylation. This signature was associated with potent provocation of NK cell effector functions and was discriminative for active antibody-mediated rejection among patients with donor specific HLA antibodies.
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