Related Experiment Video
Updated: Aug 21, 2025
11:15
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
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Human T lymphocytes at tumor sites.
Samuele Notarbartolo1, Sergio Abrignani2,3
1INGM, Istituto Nazionale Genetica Molecolare "Romeo Ed Enrica Invernizzi", Milan, Italy. notarbartolo@ingm.org.
Seminars in Immunopathology
|November 17, 2022
Summary
Resident memory T (TRM) cells offer potent antitumor immunity by residing in tissues. This review explores their generation, maintenance, and role in cancer immunity and immunotherapy, highlighting future research directions.
Area of Science:
- Immunology
- Cancer Research
- Cellular Biology
Background:
- T lymphocytes, specifically CD4+ and CD8+ T cells, are crucial for adaptive anti-tumor immunity.
- Effector T cells eliminate cancer cells, with a subset persisting as memory cells for enhanced future responses.
- Resident memory T (TRM) cells reside in tissues, offering rapid, localized immunity against cancer recurrence.
Purpose of the Study:
- To review the generation and maintenance mechanisms of TRM cells in non-lymphoid tissues.
- To elucidate the role of CD4+ and CD8+ TRM cells in antitumor immunity.
- To discuss the potential contribution of TRM cells to cancer immunotherapy efficacy.
Main Methods:
- Literature review of existing research on TRM cell generation, maintenance, and function.
- Analysis of studies investigating TRM cell involvement in antitumor responses.
- Exploration of data linking TRM cells to immunotherapy outcomes.
Main Results:
- TRM cells are generated from effector T cells and stably maintained within peripheral tissues.
- Both CD4+ and CD8+ TRM cells play significant roles in recognizing and eliminating cancer cells.
- TRM cells are implicated in the efficacy of various cancer immunotherapies.
Conclusions:
- TRM cells represent a promising cellular population for durable cancer protection due to their tissue-resident nature.
- Understanding TRM cell biology is key to improving cancer immunotherapy strategies.
- Further research, aided by new technologies, is needed to fully harness TRM cell potential in cancer treatment.
Keywords:
Cancer immunologyImmunotherapyMemory T cell differentiationT cell homingTissue-resident T cellsTrm cellsMore Related Videos
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