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Metal Complexes for Cancer Sonodynamic Therapy.

Arif Ali Mandal1, Rajesh Kushwaha1, Ashish Kumar Yadav1

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|November 17, 2022
PubMed
Summary

Metal complexes show promise as advanced sonosensitizers for sonodynamic therapy (SDT) cancer treatment. These agents overcome limitations of current materials, enabling more effective reactive oxygen species generation for tumor destruction.

Keywords:
CO gas therapyNADH oxidationmetal complexessinglet oxygensonodynamic therapy

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Sonodynamic therapy (SDT) utilizes ultrasound (US) to activate sonosensitizers for cancer treatment, leveraging US deep tissue penetration.
  • Current organic/nanomaterial sonosensitizers face limitations including insufficient reactive oxygen species (ROS) production and aggregation, hindering SDT efficacy.
  • Metal complexes offer tunable physiochemical properties, presenting a potential solution to overcome existing sonosensitizer drawbacks.

Purpose of the Study:

  • To review and introduce reported metal-based sonosensitizers for cancer sonodynamic therapy.
  • To delineate the prospects and advantages of using metal complexes as next-generation sonosensitizers.

Main Methods:

  • Literature review of metal complexes investigated as sonosensitizers.
  • Analysis of metal complex properties relevant to sonodynamic therapy, including sonostability, ROS generation, and solubility.

Main Results:

  • Metal complexes demonstrate tunable properties like sonostability, energy gaps, and ROS generation, surpassing limitations of traditional sonosensitizers.
  • These properties suggest metal complexes can enhance sonosensitizer performance in cancer treatment.

Conclusions:

  • Metal complexes represent a promising class of sonosensitizers for advancing cancer sonodynamic therapy.
  • The development of metal-based sonosensitizers offers a pathway to next-generation cancer therapeutics.