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Small molecules for combating multidrug-resistant superbug Candida auris infections

Jie Tu1, Na Liu1, Yahui Huang1

  • 1School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Acta Pharmaceutica Sinica. B
|November 17, 2022
PubMed

Insights

Candida auris is a growing global health threat due to multi-drug resistance. This review details new therapeutic strategies and drug candidates to combat challenging Candida auris infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Emerging threat of Candida auris (C. auris) as a global health concern.
  • High mortality associated with C. auris infections due to multi-drug resistance.
  • Limited current therapeutic options for treating C. auris infections.

Purpose of the Study:

  • Comprehensive review of current strategies for C. auris drug discovery and development.
  • Summarize drug resistance profiles and mechanisms of C. auris.
  • Illustrate novel therapeutic agents, including clinical candidates and drug combinations.

Main Methods:

  • Literature review of existing and emerging therapeutic strategies against C. auris.
  • Analysis of drug resistance mechanisms and profiles.
  • Detailed examination of compound structures and activities.

Main Results:

  • Overview of drug resistance in C. auris.
  • Detailed illustration of clinical candidates, drug combinations, and repositioned drugs.
  • Exploration of novel targets and compound types for C. auris treatment.

Conclusions:

  • Need for novel therapeutic agents to combat multi-drug resistant C. auris.
  • Highlighting promising drug candidates and strategies for future research.
  • Review aims to accelerate drug development against this critical fungal pathogen.
Keywords:
Antifungal agentsAntifungal targetsCandida aurisDrug resistanceVirulence factors

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