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Updated: Aug 21, 2025
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Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis
Published on: June 13, 2021
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Small molecules for combating multidrug-resistant superbug Candida auris infections.
Jie Tu1, Na Liu1, Yahui Huang1
1School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Acta Pharmaceutica Sinica. B
|November 17, 2022
Summary
Candida auris is a growing global health threat due to multi-drug resistance. This review details new therapeutic strategies and drug candidates to combat challenging Candida auris infections.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Emerging threat of Candida auris (C. auris) as a global health concern.
- High mortality associated with C. auris infections due to multi-drug resistance.
- Limited current therapeutic options for treating C. auris infections.
Purpose of the Study:
- Comprehensive review of current strategies for C. auris drug discovery and development.
- Summarize drug resistance profiles and mechanisms of C. auris.
- Illustrate novel therapeutic agents, including clinical candidates and drug combinations.
Main Methods:
- Literature review of existing and emerging therapeutic strategies against C. auris.
- Analysis of drug resistance mechanisms and profiles.
- Detailed examination of compound structures and activities.
Main Results:
- Overview of drug resistance in C. auris.
- Detailed illustration of clinical candidates, drug combinations, and repositioned drugs.
- Exploration of novel targets and compound types for C. auris treatment.
Conclusions:
- Need for novel therapeutic agents to combat multi-drug resistant C. auris.
- Highlighting promising drug candidates and strategies for future research.
- Review aims to accelerate drug development against this critical fungal pathogen.
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