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Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Francesca Castoldi1, Guido Kroemer2,3,4, Federico Pietrocola1

  • 1Department of Biosciences and Nutrition, Karolinska Institute, 14152, Huddinge, Sweden.

Oncoimmunology
|November 17, 2022
PubMed

Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.

Keywords:
Agingautophagyimmune checkpointsmitochondria

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