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Related Experiment Video

Updated: Aug 21, 2025

Intraoperative Ultrasound in Spinal Surgery
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Granulocytic sarcoma with long spinal cord compression: A case report.

Yuan-Dong Shao1,2, Xue-Hua Wang2, Lei Sun2

  • 1Department of Spine Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250000, Shandong Province, China.

World Journal of Clinical Cases
|November 17, 2022
PubMed
Summary

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Granulocytic sarcoma (GS) can present as a rare intraspinal mass causing spinal cord compression in acute myeloid leukemia (AML) patients. Chemotherapy alone effectively resolved the lesion and neurological deficits, avoiding surgery.

Area of Science:

  • Hematology
  • Oncology
  • Neurology

Background:

  • Granulocytic sarcoma (GS), an extramedullary manifestation of acute myeloid leukemia (AML), is uncommon in the central nervous system.
  • Intraspinal space-occupying lesions due to GS are rare, often necessitating surgical decompression.

Observation:

  • A 15-year-old male presented with lower limb weakness and numbness, diagnosed with AML.
  • MRI revealed extensive thoracic spinal cord compression from multiple space-occupying lesions.
  • The patient received chemotherapy prior to planned surgery.

Findings:

  • Post-chemotherapy, MRI showed complete resolution of intraspinal lesions.
  • Neurological deficits, including lower limb sensation and strength, significantly improved.
Keywords:
Acute myeloid leukemiaCase reportChemotherapyGranulocytic sarcomaIntraspinal tumorSpinal cord compression

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Implications:

  • Intraspinal GS can be an initial presentation of AML, causing severe spinal cord compression.
  • Standard chemotherapy can effectively treat intraspinal GS, relieving compression and restoring neurological function, potentially avoiding surgery.