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Published on: December 6, 2016
Relationship between lipids and sleep apnea: Mendelian randomization analysis
Lian-Peng Zhang1, Xiao-Xia Zhang2
1Department of Respiratory Medicine, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou People's Hospital, Qingzhou 262500, Shandong Province, China. hxzlp2013@126.com.
Background:
Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive.
Aim:
To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization (MR) analysis.
Methods:
Single nucleotide polymorphism (SNP) data related to serum lipids were obtained from the Global Lipids Genetics Consortium study, which included 188578 individuals of European ancestry. Additionally, sleep apnea-related SNP data were collected from the United Kingdom Biobank study, which comprised 463005 individuals of European ancestry. Two-sample MR analysis was performed to assess the causality between serum lipids and sleep apnea based on the above public data.
Results:
Genetically predicted low-density lipoprotein (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.99 to 1.00; P = 0.58), high-density lipoprotein (OR = 0.99, 95%CI = 0.99 to 1.00; P = 0.91), triglyceride (OR = 1.00, 95%CI = 0.99 to 1.00; P = 0.92), and total cholesterol (OR = 0.99, 95%CI = 0.99 to 1.00; P = 0.33) were causally unrelated to sleep apnea.
Conclusion:
Our MR analysis suggests that genetically predicted serum lipids are not risk factors of sleep apnea.
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