Related Experiment Video

Updated: Aug 21, 2025

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

6.4K

Unsolved problems in CDH follow-up

Laura Valfré1, Andrea Conforti1, Francesco Morini2

  • 1Neonatal Surgery Unit, Medical and Surgical Department of Fetus-Newborn-Infant, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Frontiers in Pediatrics
|November 17, 2022
PubMed

Insights

Improved survival in congenital diaphragmatic hernia (CDH) patients highlights the growing challenge of late-onset comorbidities. Addressing these complex, long-term health issues is crucial for ongoing CDH care and management.

Area of Science:

  • Pediatric Surgery
  • Neonatology
  • Pulmonology

Background:

  • Advances in technology and pharmacology have increased survival rates for patients with congenital diaphragmatic hernia (CDH) beyond the neonatal period.
  • This improved survival has shifted the focus towards managing complex late-onset comorbidities in CDH patients.

Purpose of the Study:

  • To highlight critical "unsolved problems" in the long-term follow-up care of CDH patients.
  • To emphasize the increasing importance of addressing late morbidity in CDH management.

Main Methods:

  • This paper is a review and discussion of existing challenges.
  • It synthesizes current knowledge on late comorbidities in CDH.

Main Results:

  • CDH survivors frequently face chronic pulmonary and cardiac dysfunctions.
  • Neurodevelopmental challenges and specific nutritional requirements are common.
  • These conditions often necessitate prolonged medical or surgical interventions.

Conclusions:

  • Late morbidity is a significant and growing concern in CDH patient care.
  • Further research and clinical strategies are needed to address the "unsolved problems" in long-term CDH follow-up.
  • Optimizing long-term outcomes requires a comprehensive approach to managing chronic comorbidities.

Keywords:
congenital diaphragmatic hernia (CDH)hearing losslong-term follow-upneurodevelopmentproblemspulmonary hypertensionthoracoscopy

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.7K
Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

6.3K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
37
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
3.7K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
19
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
27