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Published on: January 7, 2019
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3D biodegradable shape changing composite scaffold with programmable porous structures for bone engineering.
Xiaohu Chen1, Zuoxun Huang1, Qing Yang1
1College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, Sichuan, People's Republic of China.
Biomedical Materials (Bristol, England)
|November 17, 2022
Summary
This study created a novel, shape-changing polyurethane scaffold using polycaprolactone and polyethylene glycol. The hydroxyapatite-filled material shows excellent biocompatibility and osteoconductivity for bone defect repair.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Tissue Engineering
Background:
- Development of advanced scaffolds for bone defect regeneration is crucial.
- Biodegradable polymers offer potential for temporary bone support.
- Incorporating osteoconductive materials can enhance bone healing.
Purpose of the Study:
- To synthesize a biodegradable, shape-memory polyurethane scaffold.
- To investigate the effect of hydroxyapatite (HA) on scaffold properties.
- To evaluate the scaffold's suitability for bone defect implantation.
Main Methods:
- Sequential in-situ foaming, salt leaching, and freeze-drying processes.
- Incorporation of hydroxyapatite (HA) into a polycaprolactone and polyethylene glycol matrix.
- Characterization using Infrared spectroscopy, SEM, XRD, DSC, and bending tests.
- In vitro mineralization and in vivo biocompatibility assessments.
Main Results:
- Successful synthesis of a biodegradable composite porous polyurethane scaffold.
- HA addition decreased porosity, increased pore size, and lowered melting point near body temperature.
- PUHA20 exhibited excellent shape memory performance (fixity >98.9%, recovery >96.2%).
- Scaffold demonstrated good osteoconductivity and in vivo biocompatibility.
Conclusions:
- The developed HA-polyurethane scaffold possesses responsive shape-changing capabilities.
- The material shows promising osteoconductivity and biocompatibility for bone regeneration.
- This scaffold is a viable candidate for treating bone defects.
