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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Structure and interaction roles in the release profile of chalcone-loaded liposomes
Nichole Osti Silva1, Laiane Souza da Silva2, Mariele Paludetto Sanches3
1Programa de Pós Graduação em Química Tecnológica e Ambiental, Escola de Química e Alimentos- PPGQTA, Universidade Federal do Rio Grande- FURG, Av. Itália, km 8, Campus Carreiros, Rio Grande, RS 96203-900, Brazil.
Abstract:
The structures and molecular interactions of established synthetic chalcones were correlated with their release profiles from asolectin liposomes. The effects of chalcones on the properties of liposomes were evaluated by dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-VIS), horizontal attenuated total reflection Fourier transform infrared (HATR-FTIR), 31P nuclear magnetic resonance (31P NMR), zeta (ζ) potential and differential scanning calorimetry (DSC). The profiles and mechanisms of release were accessed according to the Korsmeyer-Peppas model. Results obtained allowed the establishment of a relationship between the chalcone release profile and 1) the ordering effects of chalcones in different membrane regions, 2) their polar or interfacial location in the lipid layer, 3) the influence of hydroxy and methoxy substituents, 4) their effect on reorientation of lipid choline-phosphate regions. The obtained data may improve the development of chalcone-based systems to be used in the therapy of chronic and acute diseases.
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