Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...

Pathophysiology of Cardiac Performance

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Cardiopulmonary Resuscitation IV: Pharmacological Management

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...

Heart Failure Drugs: β-Blockers

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...

Antianginal Drugs: Nitrates and β-Blockers

Antianginal Drugs: Nitrates and β-Blockers

In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

QT interval prolongation in acute antipsychotic poisoning: systematic review and recommendations.

Clinical toxicology (Philadelphia, Pa.)·2025

Same author

The successful use of buprenorphine to manage kratom withdrawal secondary to self-treatment of opioid withdrawal.

Clinical toxicology (Philadelphia, Pa.)·2025

Same author

Hemodynamics Following Dexmedetomidine Loading Dose From Infusion.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2025

Same author

Caffeine Overdose Resulting in Seizure-like Activity and Rhabdomyolysis in a Child: A Case Report.

The Journal of emergency medicine·2025

Same author

Comparative Safety of Medications for Severe Agitation: A Geriatric Emergency Department Guidelines 2.0 Systematic Review.

Journal of the American Geriatrics Society·2025

Same author

Emergency Department Programs to Support Medication Safety in Older Adults: A Systematic Review and Meta-Analysis.

JAMA network open·2025

Same journal

Why Dispelling Myths and Misconceptions in Emergency Medicine Matters.

Emergency medicine clinics of North America·2026

Same journal

Myths and Misconceptions in Emergency Medicine.

Emergency medicine clinics of North America·2026

Same journal

Acute Otitis Media-Watch and Wait Is Not a Myth.

Emergency medicine clinics of North America·2026

Same journal

Hot or Not? Myths and Misconceptions About Antipyretics for Pediatric Fever.

Emergency medicine clinics of North America·2026

Same journal

Epinephrine Improves Outcomes in Out-Of-Hospital Cardiac Arrests.

Emergency medicine clinics of North America·2026

Same journal

Myth: Pretreatment Prevents Intravenous Contrast Reactions in the Emergency Department.

Emergency medicine clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 20, 2025

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Cardiovascular Pharmacology.

Jessica M Mason¹, Michael E O'Brien², Jennifer L Koehl³

¹Department of Pharmacy, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Emergency Medicine Clinics of North America

|November 17, 2022

Summary

This summary is machine-generated.

This review covers essential pharmacologic therapies for cardiovascular emergencies like acute coronary syndromes, heart failure, and arrhythmias. It offers practical guidance for Emergency Department clinicians managing these critical conditions.

Keywords:

Arrhythmia Atrial fibrillation Cardiovascular Dosing Heart failure Medication Pharmacology Pharmacotherapy

More Related Videos

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Aug 20, 2025

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

Area of Science:

Emergency Medicine
Cardiology
Clinical Pharmacology

Background:

Cardiovascular emergencies necessitate prompt and effective pharmacologic interventions.
Acute coronary syndromes, acute heart failure, and arrhythmias are common critical conditions encountered in emergency settings.

Purpose of the Study:

To review the pharmacotherapy for key cardiovascular emergencies.
To provide practical, bedside-applicable insights for Emergency Department (ED) clinicians.

Main Methods:

Literature review of pharmacologic agents used in cardiovascular emergencies.
Focus on evidence-based therapies relevant to the ED environment.

Main Results:

Detailed review of pharmacologic options for acute coronary syndromes.
Discussion of therapeutic strategies for acute heart failure management.
Overview of antiarrhythmic drug classes and their application.

Conclusions:

Pharmacologic therapy is crucial for managing cardiovascular emergencies.
Practical knowledge of these agents enhances patient care in the ED.
This review equips clinicians with essential information for bedside decision-making.