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Updated: Aug 20, 2025
Coral Reef Arks: An In Situ Mesocosm and Toolkit for Assembling Reef Communities
Published on: January 6, 2023
Utilizing an artificial intelligence system to build the digital structural proteome of reef-building corals
Yunchi Zhu1, Xin Liao2, Tingyu Han1
1State Key Laboratory of Bioelectronics, Southeast University, Nanjing, Jiangsu, 210096, China.
Background:
Reef-building corals play an important role in the marine ecosystem, and analyzing their proteomes from a structural perspective will exert positive effects on exploring their biology. Here we integrated mass spectrometry with newly published ColabFold to obtain digital structural proteomes of dominant reef-building corals.
Results:
Of the 8,382 homologous proteins in Acropora muricata, Montipora foliosa, and Pocillopora verrucosa identified, 8,166 received predicted structures after about 4,060 GPU hours of computation. The resulting dataset covers 83.6% of residues with a confident prediction, while 25.9% have very high confidence.
Conclusions:
Our work provides insight-worthy predictions for coral research, confirms the reliability of ColabFold in practice, and is expected to be a reference case in the impending high-throughput era of structural proteomics.
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