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Individual Patient Data Validation of the EAU Definitions of BCG Failure in Patients with Non-muscle-invasive Urothelial Carcinoma of the Bladder: An International Multicenter Retrospective Study.

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French AFU Cancer Committee Guidelines - Update 2022-2024: Muscle-Invasive Bladder Cancer (MIBC).

Y Neuzillet1, F Audenet2, Y Loriot3

  • 1Service d'urologie, hôpital Foch, université Paris Saclay, Suresnes, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|November 18, 2022
PubMed
Summary
This summary is machine-generated.

Updated recommendations for muscle-invasive bladder carcinoma (MIBC) management emphasize diagnosis, treatment, and surveillance. Key updates include neoadjuvant chemotherapy before cystectomy and immunotherapy for metastatic disease.

Keywords:
BladderBladder tumoursCancerCarcinome urothélialCystectomieCystectomySurvieSurvivalTumeurs de la vessieUrothelial carcinomaVessie

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Area of Science:

  • Urology
  • Oncology

Background:

  • Muscle-invasive bladder carcinoma (MIBC) requires updated management strategies.
  • Current CCAFU recommendations need revision based on recent evidence.

Approach:

  • Systematic literature review (2020-2022) on NMIBC and MIBC diagnosis, treatment, and surveillance.
  • Evaluation of references and their levels of evidence.

Key Points:

  • MIBC diagnosis relies on maximal tumor resection, CTU, chest CT, or multiparametric MRI.
  • Cystectomy with lymphadenectomy is standard for non-metastatic MIBC, preceded by neoadjuvant chemotherapy.
  • Platinum-based chemotherapy (GC or MVAC) is first-line for metastatic MIBC; pembrolizumab shows survival benefit in second-line.

Conclusions:

  • Updated CCAFU recommendations aim to enhance patient management for MIBC.
  • Improved diagnosis and decision-making for MIBC treatment are expected outcomes.