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Organoids and Their Research Progress in Plastic and Reconstructive Surgery
Huiting Wu1,2, Guanhuier Wang1, Yujia Shang1,2
1Department of Plastic Surgery, Peking University Third Hospital, Haidian District, 49 North Garden Road, Beijing, 100191, China.
Aesthetic Plastic Surgery
|November 18, 2022
Summary
Organoids, derived from stem cells, show promise in plastic surgery for tissue repair and regeneration. This review explores their use in skin, bone, and cartilage reconstruction.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Stem Cell Biology
Background:
- Organoids are 3D stem cell-derived structures mimicking organ function.
- They are utilized in disease research, drug development, and transplantation.
- Emerging applications include using 3D materials in plastic surgery for repair and regeneration.
Purpose of the Study:
- To review the application of organoids in plastic surgery.
- To summarize recent research on organoid construction and use in tissue reconstruction.
Main Methods:
- Literature search of PubMed/MEDLINE database up to July 2022.
- Inclusion of animal and human studies.
- Keywords: Organoids, Plastic Surgery, Pluripotent Stem Cells, Bioscaffold, Skin Reconstruction, Bone and Cartilage Regeneration.
Main Results:
- Organoids offer potential for plastic surgery applications.
- Research is progressing in stem cell sources, scaffold materials, and organoid construction methods.
- Applications span skin reconstruction, bone, and cartilage regeneration.
Conclusions:
- Organoids represent a promising frontier in plastic surgery.
- Further research into stem cells, biomaterials, and construction techniques is warranted.
- Potential for enhanced tissue repair, reconstruction, and regeneration in plastic surgery.
