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Updated: Aug 20, 2025
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
DICER1 Mutation in Recurrent Ovarian Sertoli-Leydig Cell Tumor: A Case Report
Shalon Liu1, Alida J Pokoradi2, Donald Soboleski3
1Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Background:
DICER1 mutation has been linked to development of Sertoli-Leydig cell tumor and cystic nephroma, among other neoplasms.
Case:
We present a unique case of recurrent ovarian Sertoli-Leydig cell tumor in a pediatric patient with a known DICER1 mutation and history of cystic nephroma. She underwent surgical staging and adjuvant chemotherapy, and her recurrences have been treated with chemotherapy, whole-abdomen radiation therapy, and further surgical debulking.
Conclusion:
This report adds to the small body of evidence about this rare but unexpectedly highly aggressive tumor, especially in the recurrent setting, and reminds the reader of the importance of cancer diagnosis in this population.
